Počet záznamů: 1

Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles

SYSNO ASEP	0368922
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles
Tvůrce(i)	Ménová, P. (CZ) Eigner, V. (CZ) Čejka, J. (CZ) Dvořáková, H. (CZ) Šanda, Miloslav (UOCHB-X) Cibulka, R. (CZ)
Celkový počet autorů	6
Zdroj.dok.	Journal of Molecular Structure. - : Elsevier - ISSN 0022-2860 Roč. 1004, 1/3 (2011), s. 178-187
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	alloxazine adducts ; flavin adducts ; flavoenzymes ; X-ray structural analysis ; NMR spectroscopy ; UV-VIS spectroscopy
Vědní obor RIV	CC - Organická chemie
CEP	GA203/07/1246 GA ČR - Grantová agentura ČR
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000296927300024
DOI	10.1016/j.molstruc.2011.08.002
Anotace	Five flavin (isoalloxazine) and alloxazine adducts with O-nucleophiles, 5-ethyl-4a-hydroxy-3,7,8,10-tetramethyl-4a,5-dihydroisoalloxazine (1a-OH), 5-ethyl-4a-hydroxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OH), 5-ethyl-4a-methoxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OMe), 5-ethyl-4a-hydroxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OH) and 5-ethyl-4a-methoxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OMe) were prepared from the corresponding salts, 5-ethyl-3,7,8,10-tetramethylisoalloxazinium (1a), 5-ethyl-3,10-dimethylisoalloxazinium (1b) and 5-ethyl-1,3-dimethylalloxazinium (2a) perchlorates by the addition of a nucleophile (water or methanol) and triethylamine as a base. They were characterized by 1H and 13C NMR, HR-MS and UV–VIS spectra and X-ray diffraction. Flavinium and alloxazinium salts are in rapid equilibria with their adducts; the equilibrium constants for flavin adduct formation is higher by six orders of magnitude than those for alloxazine derivatives.
Pracoviště	Ústav organické chemie a biochemie
Kontakt	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Rok sběru	2012

Počet záznamů: 1