Počet záznamů: 1

An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family

SYSNO ASEP	0368706
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family
Tvůrce(i)	Gäde, G. (ZA) Šimek, Petr (BC-A)_{RID, ORCID} Marco, H. G. (ZA)
Celkový počet autorů	3
Zdroj.dok.	Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X Roč. 414, č. 3 (2011), s. 592-597
Poč.str.	6 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Insects ; stink bug ; Nezara viridula
Vědní obor RIV	ED - Fyziologie
CEP	GAP206/10/2401 GA ČR - Grantová agentura ČR
CEZ	AV0Z50070508 - ENTU-I, BC-A (2005-2011)
UT WOS	000298519500026
DOI	10.1016/j.bbrc.2011.09.127
Anotace	An octapeptide of the adipokinetic hormone (AKH) peptide family is identified in corpora cardiaca of the stink bug, Nezara viridula. This is the second AKH in N. viridula and it has a hydroxyproline residue at position 6, whereas the major AKH (known as Panbo-RPCH) has Pro as the sixth amino acid residue. Various extraction procedures were followed to ascertain whether the hydroxylation is an artefact of extraction, or whether it is due to a true post-translational modification at the prohormone level. The proline hydroxylation is unique for invertebrate neuropeptides, while it has been described in the vertebrate gonadotropin-releasing hormone (GnRH). The current finding is another piece of evidence that AKH and GnRH form a peptide superfamily and are closely related evolutionarily. Biologically, [Hyp6]-Panbo-RPCH is active in vivo as an AKH, causing hyperlipaemia in the stink bug at low doses, indicating that it is an endogenous, mature and functional hormone in this insect species.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2012

Počet záznamů: 1