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Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications

SYSNO ASEP	0367867
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve SCOPUS
Název	Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications
Tvůrce(i)	Huhn, S. (DE) Ingelfinger, D. (DE) Bermejo, J. L. (DE) Bevier, M. (DE) Pardini, Barbara (UEM-P) Naccarati, Alessio (UEM-P) Steinke, V. (DE) Rahner, N. (DE) Holinski-Feder, E. (DE) Morak, M. (DE) Schackert, H. K. (DE) Görgens, H. (DE) Pox, C. P. (DE) Goecke, T. (DE) Kloor, M. (DE) Loeffler, M. (DE) Büttner, R. (DE) Vodičková, Ludmila (UEM-P)_RID Novotný, J. (CZ) Demir, K. (DE) Cruciat, C. M. (DE) Renneberg, R. (DE) Huber, W. (DE) Niehrs, C. (DE) Boutros, M. (DE) Propping, P. (DE) Vodička, Pavel (UEM-P)_RID Hemminki, K. (DE) Försti, A. (DE)
Zdroj.dok.	International Journal of Molecular Epidemiology and Genetics - ISSN 1948-1756 Roč. 2, č. 1 (2011), s. 36-50
Poč.str.	15 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	colorectal cancer ; case-control study ; selective pressure
Vědní obor RIV	EB - Genetika a molekulární biologie
CEZ	AV0Z50390512 - UEM-P (2005-2011)
EID SCOPUS	79251574403
Anotace	Several studies have shown that susceptibility to complex diseases can be mediated by ancestral alleles. Using RNAi screening, CTNNBL1 was identified as a putative regulator of the Wnt signaling pathway, which plays a key role in colorectal carcinogenesis. We investigated whether genetic variation in CTNNBL1 affects susceptibility to CRC and tested for signals of recent selection. In the Czech cohort, containing sporadic cases, the ancestral alleles of three SNPs showed evidence of association with CRC: rs2344481 (OR 1.44, 95%CI 1.06-1.95, dominant model), rs2281148 (OR 0.59, 95%CI 0.36-0.96, dominant model) and rs2235460 (OR 1.38, 95%CI 1.01-1.89, AA vs. GG). The associations were less prominent in the family/early onset-based German cohort. Data derived from several databases and statistical tests
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2012

Počet záznamů: 1