Počet záznamů: 1
QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock
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SYSNO ASEP 0367836 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock Tvůrce(i) Chen, K. F. (GB)
Peschel, N. (GB)
Závodská, Radka (BC-A) RID, ORCID
Sehadová, Hana (BC-A) RID, ORCID
Stanewsky, R. (GB)Celkový počet autorů 5 Zdroj.dok. Current Biology. - : Cell Press - ISSN 0960-9822
Roč. 21, č. 9 (2011), s. 719-729Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova QUASIMODO ; Drosophila ; circadian clock Vědní obor RIV ED - Fyziologie CEP LC07032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000290553800021 DOI 10.1016/j.cub.2011.03.049 Anotace We identified a novel clock-controlled gene (quasimodo), which encodes a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent TIM degradation. Whereas wild type flies become arrhythmic in constant light (LL), quasimodo mutants elicit rhythmic expression of clock proteins and behavior in LL. QUASIMODO can function independently of CRY and is predominantly expressed within the CRY-negative DN3 clock neurons. Interestingly, downregulation of qsm in the clock circuit restores LL PERIOD protein rhythms in the qsm-negative DN1, indicating that qsm-mediated light-input is not cell-autonomous and can be accessed by the clock circuit. Our findings indicate that QUASIMODO constitutes part of a novel light-input to the circadian clock. Its light-responsive character in conjunction with the predicted localization at the outer neuronal membrane, suggests that QUASIMODO function is linked to electrical properties of clock neurons. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2012
Počet záznamů: 1