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Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
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SYSNO ASEP 0367668 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro Tvůrce(i) Hošek, J. (CZ)
Bartoš, M. (CZ)
Chudík, S. (CZ)
Dall’Acqua, S. (IT)
Innocenti, G. (GB)
Kartal, M. (TR)
Kokoška, L. (CZ)
Kollár, P. (CZ)
Kutil, Zsófia (UEB-Q)
Landa, Přemysl (UEB-Q) RID, ORCID
Marek, R. (CZ)
Závalová, V. (CZ)
Žemlička, M. (CZ)
Šmejkal, K. (CZ)Zdroj.dok. Journal of Natural Products. - : American Chemical Society - ISSN 0163-3864
Roč. 74, č. 4 (2011), s. 614-619Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova NF-KAPPA-B ; CUDRANIA-TRICUSPIDATA ; ROOT BARK Vědní obor RIV GM - Potravinářství CEP LC06030 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GP525/09/P528 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000289742300011 DOI 10.1021/np100638h Anotace Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound acts as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2012
Počet záznamů: 1