Počet záznamů: 1
Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
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SYSNO ASEP 0367248 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease Tvůrce(i) Lake, A.D. (US)
Novák, Petr (BC-A) RID, ORCID
Fisher, C.D. (US)
Jackson, J.P. (US)
Hardwick, R.N. (US)
Billheimer, D.D. (US)
Klimecki, W.T. (US)
Cherrington, N.J. (US)Celkový počet autorů 8 Zdroj.dok. Drug Metabolism and Disposition - ISSN 0090-9556
Roč. 39, č. 10 (2011), s. 1954-1960Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Steatosis ; Steatohepatitis ; Nonalcoholic fatty liver disease Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50510513 - UMBR-M, BC-A (2005-2011) UT WOS 000295026600023 DOI 10.1124/dmd.111.040592 Anotace Nonalcoholic fatty liver disease (NAFLD) is characterized by a series of pathological changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The objective of this study is to describe changes in global gene expression associated with the progression of human NAFLD. This study is focused on the expression levels of genes responsible for the absorption, distribution, metabolism, and elimination (ADME) of drugs. Differential gene expression between three clinically defined pathological groups-normal, steatosis, and NASH-was analyzed.The results suggest that uptake transporter genes are coordinately targeted for down-regulation at the global level during the pathological development of NASH and that these patients may have decreased drug uptake capacity. This coordinated regulation of uptake transporter genes is indicative of a hepatoprotective mechanism acting to prevent accumulation of toxic intermediates in disease-compromised hepatocytes. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2012
Počet záznamů: 1