Počet záznamů: 1

Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system

SYSNO ASEP	0367199
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system
Tvůrce(i)	Burešová, Veronika (BC-A)_{RID, ORCID} Hajdušek, Ondřej (BC-A)_{RID, ORCID} Franta, Zdeněk (BC-A) Loosová, Gabriela (BC-A) Grunclová, Lenka (BC-A) Levashina, E.A. (FR) Kopáček, Petr (BC-A)_{RID, ORCID}
Zdroj.dok.	Journal of Innate Immunity - ISSN 1662-811X Roč. 3, č. 6 (2011), s. 623-630
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	tick ; thioester-containing proteins ; complement
Vědní obor RIV	EC - Imunologie
CEP	GAP506/10/2136 GA ČR - Grantová agentura ČR
	LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000296368900010
DOI	10.1159/000328851
Anotace	Parasite survival inside the tick relies on the ability of a pathogen to escape or inhibit tick immune defenses, but the molecular interactions between the tick and its pathogens remain poorly understood. Here we report that tick genomes are unique in that they contain all known classes of the α2-macroglobulin family (α2M-F) proteins: α2-macroglobulin pan-protease inhibitors, C3 complement components, and insect thioester-containing and macroglobulin-related proteins. RNA interference-mediated gene silencing in the hard tick Ixodes ricinus revealed the central role of a C3-like molecule in the phagocytosis of bacteria and specific functions for α2M-F proteins. Assessment of α2M-F functions in a single organism should significantly contribute to the general knowledge on the evolution and function of the complement system. This publication was accomplished in co-operatin with Prof. Jules A. Hoffmann, the Nobel Prize laureate 2011 in Medicine and Physiology (see acknowledgements).
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2012

Počet záznamů: 1