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Novel star HPMA-based polymer conjugates for passive targeting to solid tumors
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SYSNO ASEP 0367005 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Novel star HPMA-based polymer conjugates for passive targeting to solid tumors Tvůrce(i) Etrych, Tomáš (UMCH-V) RID, ORCID
Strohalm, Jiří (UMCH-V)
Chytil, Petr (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDZdroj.dok. Journal of Drug Targeting - ISSN 1061-186X
Roč. 19, č. 10 (2011), s. 874-889Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova drug delivery ; controlled release ; HPMA Vědní obor RIV CD - Makromolekulární chemie CEP IAA400500806 GA AV ČR - Akademie věd IAAX00500803 GA AV ČR - Akademie věd GAP301/11/0325 GA ČR - Grantová agentura ČR CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000297057100003 DOI 10.3109/1061186X.2011.622402 Anotace Novel star polymer-doxorubicin conjugates designed for passive tumor targeting have been developed and their potential for treatment of cancer has been investigated. In the present study the synthesis, physico-chemical characterization, drug release, bio-distribution and preliminary data of in vivo efficacy of the conjugates are described. In the water-soluble conjugates the core of a molecule formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds enabling intracellular pH-controlled hydrolytic drug release, or by GFLG sequence susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of polymer conjugates in a broad range of molecular weights. The star polymer-Dox conjugates showed significantly higher anti-tumor activity in vivo than Dox HCl or its linear or graft polymer conjugates. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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