Počet záznamů: 1
Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors
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SYSNO ASEP 0366522 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors Tvůrce(i) Drozdová, Anna (MBU-M)
Bojarová, Pavla (MBU-M) ORCID
Křenek, Karel (MBU-M)
Weignerová, Lenka (MBU-M) RID
Hensen, B. (DE)
Elling, L. (DE)
Christensen, H. (DK)
Jensen, H.H. (DK)
Pelantová, Helena (MBU-M) ORCID, RID
Kuzma, Marek (MBU-M) ORCID, RID
Bezouška, Karel (MBU-M)
Krupová, Monika (MBU-M)
Adámek, David (MBU-M)
Slámová, Kristýna (MBU-M) RID, ORCID
Křen, Vladimír (MBU-M) RID, ORCIDZdroj.dok. Carbohydrate Research. - : Elsevier - ISSN 0008-6215
Roč. 346, č. 12 (2011), s. 1599-1609Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova beta-N-Acetylhexosaminidase ; alactosyltransferase ; Enzymatic glycosylation Vědní obor RIV CE - Biochemie CEP GP203/09/P024 GA ČR - Grantová agentura ČR GD305/09/H008 GA ČR - Grantová agentura ČR GA303/09/0477 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000292852100029 DOI 10.1016/j.carres.2011.04.043 Anotace This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2012
Počet záznamů: 1