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Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces
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SYSNO ASEP 0366346 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces Tvůrce(i) Řezanka, Tomáš (MBU-M) ORCID
Siřišťová, L. (CZ)
Schreiberová, O. (CZ)
Řezanka, M. (CZ)
Masák, J. (CZ)
Melzoch, K. (CZ)
Sigler, Karel (MBU-M) RIDZdroj.dok. Environmental Microbiology. - : Wiley - ISSN 1462-2912
Roč. 13, č. 6 (2011), s. 1577-1589Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova PERFORMANCE LIQUID-CHROMATOGRAPHY ; AVERMECTIN BIOSYNTHESIS ; SELECTIVE PRODUCTION Vědní obor RIV EE - Mikrobiologie, virologie CEP 2B08062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000291268900017 DOI 10.1111/j.1462-2920.2011.02465.x Anotace A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2012
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