Počet záznamů: 1

Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury

SYSNO ASEP	0366090
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury
Tvůrce(i)	Arboleda Toro, David (UEM-P) Forostyak, Serhiy (UEM-P)_{RID, ORCID} Jendelová, Pavla (UEM-P)_{RID, ORCID} Mareková, Dana (UEM-P) Amemori, Takashi (UEM-P)_RID Pivoňková, Helena (UEM-P) Mašínová, Katarína (UEM-P) Syková, Eva (UEM-P)_RID
Zdroj.dok.	Cellular and Molecular Neurobiology. - : Springer - ISSN 0272-4340 Roč. 31, č. 7 (2011), s. 1113-1122
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Adipose tissue ; Differentiation ; Mesenchymal stromal cells
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
CEP	GA305/09/0717 GA ČR - Grantová agentura ČR
	IAA500390902 GA AV ČR - Akademie věd
CEZ	AV0Z50390512 - UEM-P (2005-2011)
	AV0Z50390703 - UEM-P (2007-2013)
UT WOS	000295169500017
DOI	10.1007/s10571-011-9712-3
Anotace	The purpose of the study was to compare predifferentiated ASCs (pASCs) with naïve ASCs in vitro and after transplantation into rats with a balloon-induced spinal cord compression lesion. ASC spheres were induced prior to transplantation, then pASCs or ASCs were injected intraspinally. Behavioral, histological and electrophysiological methods were used to assess the cells' fate and the rats' functional outcome.The predifferentiation of ASCs facilitated the protection of denuded axons; however, functional improvement was comparable in both groups, indicating that repair was induced mainly through paracrine mechanisms.
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2012

Počet záznamů: 1