Počet záznamů: 1
Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons
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SYSNO ASEP 0365816 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons Tvůrce(i) Andrysík, Zdeněk (BFU-R)
Vondráček, Jan (BFU-R) RID, ORCID
Marvanová, S. (CZ)
Ciganek, M. (CZ)
Neča, J. (CZ)
Pěnčíková, K. (CZ)
Mahadevan, B. (US)
Topinka, Jan (UEM-P) RID, ORCID
Baird, W.M. (US)
Kozubík, Alois (BFU-R) RID, ORCID
Machala, M. (CZ)Celkový počet autorů 11 Zdroj.dok. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 714, 1-2 (2011), s. 53-62Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova urban air pollution ; PAHs ; AhR Vědní obor RIV BO - Biofyzika CEP GA310/07/0961 GA ČR - Grantová agentura ČR CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000294937700007 DOI 10.1016/j.mrfmmm.2011.06.011 Anotace In the present study we used an organic extract of the urban dust standard reference material, SRM1649a, as a model mixture to study a range of toxic effects related to DNA damage and AhR activation. We found that this extract, as well as its neutral and polar fractions, were potent inducers of a range of AhR-mediated responses. Importantly, these toxic events occurred at doses one order of magnitude lower than induction of DNA damage. Our data suggested that more attention should be paid to the AhR-dependent nongenotoxic events elicited by urban air particulate matter constituents, especially polycyclic aromatic hydrocarbons and their derivatives. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2012
Počet záznamů: 1