Počet záznamů: 1
Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions
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SYSNO ASEP 0365161 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions Tvůrce(i) Macková, Hana (UMCH-V) RID
Proks, Vladimír (UMCH-V) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCID
Kučka, Jan (UMCH-V) RID, ORCID
Trchová, Miroslava (UMCH-V) RID, ORCIDZdroj.dok. Journal of Polymer Science. Part A - Polymer Chemistry. - : WILEY-BLACKWELL - ISSN 0887-624X
Roč. 49, č. 22 (2011), s. 4820-4829Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova click chemistry ; magnetic ; microspheres Vědní obor RIV CD - Makromolekulární chemie CEP KJB400500904 GA AV ČR - Akademie věd KAN401220801 GA AV ČR - Akademie věd GAP503/10/0664 GA ČR - Grantová agentura ČR CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000296255900013 DOI 10.1002/pola.24930 Anotace Magnetic poly(N-propargylacrylamide) (PPRAAm) microspheres were prepared by the precipitation polymerization of N-propargylacrylamide in a toluene/propan-2-ol medium in the presence of magnetic nanoparticles. The effects of polymerization parameters, including the polarity of the medium, polymerization temperature, the concentration of monomer, and the amount of magnetite in the polymerization feed, were examined. The microspheres were characterized in terms of their morphology, size, distribution, and iron content using TEM, SEM and AAS. As expected, Oleic acid-coated Fe3O4 nanoparticles contributed to the stabilization of the magnetic microspheres. Alkyne groups in magnetic PPRAAm microspheres were detected by IR. Microspheres were used as the anchor to enable a ‘‘click’’ reaction with an azido-end-functionalized model peptide (radiolabeled azidopentanoyl-GGGRGDSGGGY(125I)-NH2) and 4-azidophenylalanine using a Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction in water. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
Počet záznamů: 1