Počet záznamů: 1
PRR7 Is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis
- 1.
SYSNO ASEP 0365069 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název PRR7 Is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis Tvůrce(i) Hrdinka, Matouš (UMG-J)
Dráber, Peter (UMG-J)
Štěpánek, Ondřej (UMG-J) RID, ORCID
Ormsby, Tereza (UMG-J)
Otáhal, Pavel (UMG-J) RID
Angelisová, Pavla (UMG-J) RID
Brdička, Tomáš (UMG-J) RID
Pačes, Jan (UMG-J) RID, ORCID
Hořejší, Václav (UMG-J) RID
Drbal, Karel (UMG-J)Zdroj.dok. Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 286, č. 22 (2011), s. 19617-19629Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova PRR7 ; transmembrane adaptor protein ; apoptosis Vědní obor RIV EB - Genetika a molekulární biologie CEP 1M0506 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000291027700045 DOI 10.1074/jbc.M110.175117 Anotace A highly conserved ransmembrane adaptor protein (TRAP) PRR7 was found to be readily up-regulated in activated human peripheral blood lymphocytes. Transient overexpression of PRR7 in Jurkat T cell line led to gradual apoptotic death dependent on the WW domain binding motif surrounding Tyr-166 in the intracellular part of PRR7. Jurkat clones with inducible expression of PRR7 (J-iPRR7) were generated. In these cells acute induction of PRR7 expression had a dual effect. It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment. Expression of PRR7 inhibited general tyrosine phosphorylation and calcium influx after T cell receptor cross-linking by antibodies. PRR7 was constitutively tyrosine-phosphorylated and associated with Src. PRR7 is a potential regulator of signaling and apoptosis in activated T cells. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
Počet záznamů: 1