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Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies
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SYSNO ASEP 0364992 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies Tvůrce(i) Hrubý, Martin (UMCH-V) RID, ORCID
Škodová, Michaela (UMCH-V) RID
Macková, Hana (UMCH-V) RID
Skopal, Jan (UMCH-V)
Tomeš, Marek (UJF-V) RID
Kropáček, Martin (UJF-V) RID
Zimová, Jana (UJF-V) RID
Kučka, Jan (UMCH-V) RID, ORCIDZdroj.dok. Reactive and Functional Polymers. - : Elsevier - ISSN 1381-5148
Roč. 71, č. 12 (2011), s. 1155-1159Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova macroporous chelating beads ; radioembolization ; quinoline-8-ol Vědní obor RIV CD - Makromolekulární chemie CEP GPP207/10/P054 GA ČR - Grantová agentura ČR 1M0505 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z10480505 - UJF-V (2005-2011) UT WOS 000297524300005 DOI 10.1016/j.reactfunctpolym.2011.09.003 Anotace We describe the synthesis, characterization and radiochemical studies on macroporous chelating polymer beads as carriers of beta-emitters lutetium-177 and iodine-131 intended for radioembolization of liver tumors. All the polymers were labeled quantitatively by lutetium-177 in ammonium acetate buffer, DOTA containing beads however required heating to 80 °C while the quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties containing polymers were quantitatively radiolabeled within 1 h at room temperature. The quinoline-8-ol groups containing polymer was radioiodinated in 95% yield by a chloramine method. Both lutetium-177 and iodine-131 radiolabels were stable in an in vitro study in rat blood plasma. Quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties are thus more suitable for the radiolabeling of macroporous beads with lutetium-177 for radioembolization purposes than well-established DOTA. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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