Počet záznamů: 1
Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity
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SYSNO ASEP 0364839 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity Tvůrce(i) Calvo, E. (US)
Mizurini, D.M. (BR)
Sa-Nunes, A. (US)
Ribeiro, J.M.C. (US)
Andersen, J. F. (US)
Mans, B.J. (US)
Monteiro, R.Q. (BR)
Kotsyfakis, Michalis (BC-A) RID, ORCID
Francischetti, I.M.B. (US)Zdroj.dok. Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 286, č. 32 (2011), 27998-28010Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova serpin ; mosquito ; Aedes albopictus ; phospholipids ; Factor Xa ; heparin ; binding affinity ; coagulation ; thrombus ; bleeding Vědní obor RIV GJ - Choroby a škůdci zvířat, veterinární medicína CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000293557800018 DOI 10.1074/jbc.M111.247924 Anotace The function of a mosquito anticoagulant serpin named as Alboserpin is presented. The recombinant protein binds to phospholipids and it inhibits the activity of human coagulation factor Xa. Binding is highly specific and is not detectable for FX, catalytic site-blocked FXa, thrombin and 12 other enzymes. Alboserpin displays high-affinity binding to heparin, but no change in FXa inhibition was observed in the presence of the cofactor, implying that bridging mechanisms did not take place. Alboserpin displays a potent pharmacological activity since it prevents thrombus formation provoked by ferric chloride injury of the carotid artery and it increases bleeding in a dose-dependent manner. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2012
Počet záznamů: 1