Počet záznamů: 1

Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?

SYSNO ASEP	0364837
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?
Tvůrce(i)	Flegontov, Pavel (BC-A)_{RID, ORCID} Gray, M.W. (CA) Burger, G. (CA) Lukeš, Julius (BC-A)_{RID, ORCID}
Zdroj.dok.	Current Genetics. - : Springer - ISSN 0172-8083 Roč. 57, č. 4 (2011), 225-232
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	DE - Německo
Klíč. slova	Euglena ; Diplonema ; Mitochondrial genome ; RNA editing ; Constructive neutral evolution
Vědní obor RIV	EB - Genetika a molekulární biologie
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000292977000001
DOI	10.1007/s00294-011-0340-8
Anotace	Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the emergence of these highly divergent mtDNA types and the existence of insertion/deletion RNA editing (in kinetoplastids) and trans-splicing (in diplonemids), we propose that in the mitochondrion of the common evolutionary ancestor of Euglenozoa, small expressed gene fragments promoted a rampant neutral evolutionary pathway. Interactions between small antisense transcripts of these gene fragments and full-length transcripts, assisted by RNA-processing enzymes, permitted the emergence of RNA editing and/or trans-splicing activities, allowing the system to tolerate indel mutations and further gene fragmentation, respectively, and leading to accumulation of additional mutations. In this way, dramatically different mitochondrial genome structures and RNA-processing machineries were able to evolve.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2012

Počet záznamů: 1