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Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms
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SYSNO ASEP 0364747 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis Tvůrce(i) Kašný, M. (CZ)
Mikeš, L. (CZ)
Dolečková, K. (CZ)
Hampl, V. (CZ)
Dvořák, Jan (BC-A)
Novotný, M. (CZ)
Horák, P. (CZ)Zdroj.dok. Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms. - BERLIN : SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197, 2011 / Robinson M.D. ; Dalton J.P. - ISSN 0065-2598 - ISBN 978-1-4419-8413-5 Rozsah stran s. 136-154 Poč.str. 19 s. Poč.str.knihy 222 Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Trichobilharzia ; trematode ; Schistosoma ; Fasciola ; peptidase ; cercarial elastase ; cathepsin ; hydrolysis ; blood digestion ; tissue migration ; biochemical characterization ; phylogeny ; function Vědní obor RIV GJ - Choroby a škůdci zvířat, veterinární medicína CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000289378600009 DOI 10.1007/978-1-4419-8414-2 Anotace Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts, their larvae -cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts. Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host. These enzymes are indispensable bio catalysts in a number of basal biological processes and host parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2012
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