Počet záznamů: 1
Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor
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SYSNO ASEP 0364584 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor Tvůrce(i) Hovořáková, Mária (UEM-P) RID
Procházka, Jan (UEM-P)
Lesot, H. (FR)
Smrčková, Lucie (UEM-P)
Churavá, Svatava (UEM-P)
Boráň, T. (CZ)
Kozmik, Zbyněk (UMG-J) RID
Klein, O. (US)
Peterková, Renata (UEM-P) RID
Peterka, Miroslav (UEM-P) RIDZdroj.dok. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. - : Wiley - ISSN 1552-5007
346B, č. 5 (2011), s. 347-358Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova morphogenesis ; human embryos ; deciduous dentition Vědní obor RIV EA - Morfologické obory a cytologie CEP GA304/07/0223 GA ČR - Grantová agentura ČR GA304/09/1579 GA ČR - Grantová agentura ČR CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50520514 - UMG-J (2005-2011) UT WOS 000291699400005 EID SCOPUS 79958773694 DOI 10.1002/jez.b.21408 Anotace Using a combination of histology, 3D reconstructions and Shh whole mount in situ hybridization (WISH) analyses, several Sonic hedgehog (Shh) expression domains have been shown sequentially appearing in the lower WT mouse incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, two spatially distinct regions of Shh expression have been identified that appeared in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so-called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. These findings strongly suggest the necessity to re-interpret previous results based on either morphology alone or on the detection of signaling molecules alone, and offer a new insight into the interpretation of existing data from mutant mice. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2012
Počet záznamů: 1