Počet záznamů: 1

The inhibition of fat cell proliferation by fatty acids in dietary obese mice

  1. 1.
    SYSNO ASEP0364484
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    NázevThe inhibition of fat cell proliferation by fatty acids in dietary obese mice
    Tvůrce(i)Hensler, Michal (FGU-C) - Bardová, Kristina (FGU-C) - Macek Jílková, Zuzana (FGU-C) - Wahli, W. (CH) - Meztger, D. (FR) - Chambon, P. (FR) - Kopecký, Jan (FGU-C) - Flachs, Pavel (FGU-C)
    Rozsah stran128
    Zdroj.dok.Lipids in Health and Disease - ISSN 1476-511X
    Poč.str.7 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaDHA and EPA ; fish oil ; fat cell turnover
    Vědní obor RIVFB - Endokrinologie, diabetologie, metabolizmus, výživa
    CEPGAP301/11/0226 GA ČR - Grantová agentura ČR
    GD305/08/H037 GA ČR - Grantová agentura ČR
    CEZAV0Z50110509 - FGU-C (2005-2011)
    AnotaceA model of inducible and reversible lipoatrophy (aP2-Cre-ERT2 PPARγL2/L2 mice) was used, in which the death of mature adipocytes could be achieved by a selective ablation of peroxisome proliferator-activated receptor γ in response to i.p. injection of tamoxifen. The results document that dietary LC n-3 PUFA could decrease adiposity in obese mice by a mechanism, which depends on counteraction of both, differentiation and proliferation of adipose cells. These results also support the notion that adiposity is closely linked to the control of fat cell turnover and that mechanisms could exist, which control fat cell proliferation independent of energy balance
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2012