Počet záznamů: 1
Poly(ethylene oxide) layers grafted to dopamine-melanin anchoring layer: stability and resistance to protein adsorption
- 1.
SYSNO ASEP 0364383 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Poly(ethylene oxide) layers grafted to dopamine-melanin anchoring layer: stability and resistance to protein adsorption Tvůrce(i) Pop-Georgievski, Ognen (UMCH-V) RID, ORCID
Popelka, Štěpán (UMCH-V) RID
Houska, Milan (UMCH-V) RID
Chvostová, Dagmar (FZU-D) RID, SAI, ORCID
Proks, Vladimír (UMCH-V) RID, ORCID
Rypáček, František (UMCH-V) RIDZdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 12, č. 9 (2011), s. 3232-3242Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova dopamine-melanin ; polydopamine ; poly(ethylene oxide) Vědní obor RIV CD - Makromolekulární chemie CEP KJB400500904 GA AV ČR - Akademie věd GAP108/11/1857 GA ČR - Grantová agentura ČR GPP207/10/P569 GA ČR - Grantová agentura ČR CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z10100522 - FZU-D (2005-2011) UT WOS 000294699000015 DOI 10.1021/bm2007086 Anotace In this study, we propose substrate-independent modification for creating a protein-repellent surface based on dopamine-melanin anchoring layer used for subsequent binding of poly(ethylene oxide) (PEO) from melt. We verified that the dopamine-melanin layer can be formed on literally any substrate and could serve as the anchoring layer for subsequent grafting of PEO chains. Grafting of PEO from melt in a temperature range 70–110 °C produces densely packed PEO layers showing exceptionally low protein adsorption when exposed to the whole blood serum or plasma. The PEO layers prepared from melt at 110 °C retained the protein repellent properties for as long as 10 days after their exposure to physiological-like conditions. The PEO-dopamine-melanin modification represents a simple and universal surface modification method for the preparation of protein repellent surfaces that could serve as a nonfouling background in various applications, such as optical biosensors and tissue engineering. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
Počet záznamů: 1