Počet záznamů: 1
Genetic control of resistance to Trypanosoma brucei brucei infection in mice
- 1.
SYSNO ASEP 0363620 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic control of resistance to Trypanosoma brucei brucei infection in mice Tvůrce(i) Šíma, Matyáš (UMG-J) ORCID
Havelková, Helena (UMG-J)
Quan, L. (US)
Svobodová, M. (CZ)
Jarošíková, T. (CZ)
Vojtíšková, Jarmila (UMG-J)
Stassen, A. P. M. (NL)
Demant, P. (US)
Lipoldová, Marie (UMG-J) RIDZdroj.dok. PLoS Neglected Tropical Diseases. - : Public Library of Science - ISSN 1935-2735
Roč. 5, č. 6 (2011), e1173Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Trypanosoma brucei brucei ; mouse recombinant congenic strains ; Tbbr Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500520606 GA AV ČR - Akademie věd LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000292139600018 DOI 10.1371/journal.pntd.0001173 Anotace Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
Počet záznamů: 1