Počet záznamů: 1
Mitochondrially targeted anti-cancer agents
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SYSNO ASEP 0361635 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondrially targeted anti-cancer agents Tvůrce(i) Biasutto, L. (IT)
Dong, L.A. (AU)
Zoratti, M. (IT)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Mitochondrion. - : Elsevier - ISSN 1567-7249
Roč. 10, č. 6 (2010), s. 670-681Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Mitochondrial targeting ; pro-oxidant effect ; reactive oxygen species Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000284660000011 DOI 10.1016/j.mito.2010.06.004 Anotace Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification of such structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1