Počet záznamů: 1
Radiation damage to DNA in DNA-protein complexes
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SYSNO ASEP 0361467 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Radiation damage to DNA in DNA-protein complexes Tvůrce(i) Spotheim Maurizot, M. (FR)
Davídková, Marie (UJF-V) RID, ORCID, SAIZdroj.dok. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 711, 1-2 (2011), s. 41-48Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova DNA-protein complex ; ionizing radiation ; molecular structure Vědní obor RIV BO - Biofyzika CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000291914700005 DOI 10.1016/j.mrfmmm.2011.02.003 Anotace The most aggressive product of water radiolysis, the hydroxyl (OH) radical, is responsible for the indirect effect of ionizing radiations on DNA in solution and aerobic conditions. Monte-Carlo based model RADACK, allows calculating the relative probability of damage of each nucleotide of DNA irradiated alone or in complexes with proteins. The confrontation of the calculated values with the results of the radiolytic footprinting experiments together with molecular modeling calculations show that: (1) the extent and location of the lesions are strongly dependent on the structure of DNA, which in turns is modulated by the base sequence and by the binding of proteins and (2) the regions in contact with the protein can be protected against the attack by the hydroxyl radicals via masking of the binding site and by scavenging of the radicals. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2012
Počet záznamů: 1