Počet záznamů: 1
Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8(+) T-Cells
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SYSNO ASEP 0361425 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8(+) T-Cells Tvůrce(i) Růžek, Daniel (BC-A) RID, ORCID
Salát, Jiří (BC-A) RID, ORCID
Singh, S. K. (IN)
Kopecký, Jan (BC-A) RIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 5 (2011), e20472Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova CENTRAL-NERVOUS-SYSTEM ; WEST-NILE-VIRUS ; MICROVASCULAR ENDOTHELIAL-CELLS ; TIGHT JUNCTION PROTEINS ; MULTIPLE-SCLEROSIS ; INFLAMMATORY RESPONSE ; PERMEABILITY CHANGES Vědní obor RIV EB - Genetika a molekulární biologie CEP GPP302/10/P438 GA ČR - Grantová agentura ČR GAP502/11/2116 GA ČR - Grantová agentura ČR LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000291005200058 DOI 10.1371/journal.pone.0020472 Anotace Tick-borne encephalitis (TBE) virus causes severe encephalitis with serious sequelae in humans. The disease is characterized by fever and debilitating encephalitis that can progress to chronic illness or fatal infection. In this study, changes in permeability of the blood-brain barrier (BBB) in two susceptible animal models (BALB/c, and C57Bl/6 mice) infected with TBE virus were investigated at various days after infection by measuring fluorescence in brain homogenates after intraperitoneal injection of sodium fluorescein, a compound that is normally excluded from the central nervous system. We demonstrate here that TBE virus infection, in addition to causing fatal encephalitis in mice, induces considerable breakdown of the BBB. Breakdown of the BBB was also observed in mice deficient in CD8(+) T-cells, indicating that these cells are not necessary for the increase in BBB permeability that occurs during TBE. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2012
Počet záznamů: 1