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Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces
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SYSNO ASEP 0360787 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces Tvůrce(i) Rodriguez-Emmenegger, Cesar Adolfo (UMCH-V) RID
Brynda, Eduard (UMCH-V) RID
Riedel, Tomáš (UMCH-V) RID, ORCID
Houska, Milan (UMCH-V) RID
Šubr, Vladimír (UMCH-V) RID, ORCID
Bologna Alles, A. (UY)
Hasan, E. (GB)
Gautrot, J. E. (GB)
Huck, W. T. S. (GB)Zdroj.dok. Macromolecular Rapid Communications. - : Wiley - ISSN 1022-1336
Roč. 32, č. 13 (2011), s. 952-957Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova biosensors ; blood plasma ; HPMA Vědní obor RIV CD - Makromolekulární chemie CEP KAN200670701 GA AV ČR - Akademie věd IAAX00500803 GA AV ČR - Akademie věd CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000292547100002 DOI 10.1002/marc.201100189 Anotace Ultra-low-fouling poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes have been synthesized for the first time. Similar to the so far only ultra-low-fouling surface, poly(carboxybetaine acrylamide), the level of blood plasma fouling was below the detection limit of surface plasmon resonance (SPR, 0.03 ng • cm−2) despite being a hydrogen bond donor and displaying a moderate wettability, thus challenging the currently accepted views for the design of antifouling properties. The antifouling properties were preserved even after two years of storage. To demonstrate the potential of poly(HPMA) brushes for the preparation of bioactive ultra-low fouling surfaces a label-free SPR immunosensor for detection of G Streptococcus was prepared. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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