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Latent Microsporidial Infection in Immunocompetent Individuals – A Longitudinal Study
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SYSNO ASEP 0360132 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Latent Microsporidial Infection in Immunocompetent Individuals – A Longitudinal Study Tvůrce(i) Sak, Bohumil (BC-A) RID, ORCID
Kváč, Martin (BC-A) RID, RID, ORCID
Kučerová, Z. (US)
Květoňová, Dana (BC-A) SAI
Saková, Kamila (BC-A)Zdroj.dok. PLoS Neglected Tropical Diseases. - : Public Library of Science - ISSN 1935-2735
Roč. 5, č. 5 (2011), e1162Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Microsporidia ; AIDS ; indirect immunofluorescence assay ; Encephalitozoon ; immunosupression Vědní obor RIV EC - Imunologie CEP KJB500960701 GA AV ČR - Akademie věd GP523/07/P117 GA ČR - Grantová agentura ČR CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000291099100032 DOI 10.1371/journal.pntd.0001162 Anotace Microsporidia (Fungi) have been repeatedly identified as the cause of opportunistic infections predominantly in immunodeficient individuals such as AIDS patients. However, the global epidemiology of human microsporidiosis is poorly understood and the ability of microsporidia to survive and multiply in immunocompetent hosts remains unsolved. Sera, urine and stool originating from 15 persons (HIV-negative people at risk with occupational exposure to animals, aged 22–56 years, living in the Czech Republic) have been tested by indirect immunofluorescence assay (IFA) for the presence of specific anti-microsporidial antibodies, standard Calcofluor M2R staining for the detection of microsporidian spores in all urine sediments and stool smears and molecular methods for the microsporidial species determination. Our data clearly show that exposure to microsporidia is common and chronic microsporidiosis is not linked to any clinical manifestation in healthy population. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2012
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