Počet záznamů: 1
Mitochondrial targeting of [alpha]-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy
- 1.
SYSNO ASEP 0360075 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondrial targeting of [alpha]-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy Tvůrce(i) Dong, L.-F. (AU)
Jameson, V.J.A. (NZ)
Tilly, D. (AU)
Procházka, L. (CZ)
Rohlena, Jakub (BTO-N) RID, ORCID
Vališ, Karel (BTO-N)
Truksa, Jaroslav (BTO-N) RID, ORCID
Zobalová, Renata (BTO-N) RID
Mandavian, E. (US)
Klučková, Katarína (BTO-N) RID
Stantic, M. (AU)
Štursa, Jan (UOCHB-X)
Freeman, R. (AU)
Witting, P.K. (AU)
Norberg, E. (SE)
Goodwin, J. (AU)
Salvatore, B.A. (US)
Novotná, Jana (BTO-N) RID
Turánek, J. (CZ)
Ledvina, Miroslav (UOCHB-X) RID
Hozák, Pavel (UMG-J) RID, ORCID
Zhivotovsky, B. (SE)
Coster, M. (AU)
Ralph, S.J. (AU)
Smith, R.A.J. (NZ)
Neužil, Jiří (BTO-N) RIDCelkový počet autorů 26 Zdroj.dok. Free Radical Biology and Medicine. - : Elsevier - ISSN 0891-5849
Roč. 50, č. 11 (2011), s. 1546-1555Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Triphenyl phosphonium ; reactive oxygen species ; apoptosis Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/08/0811 GA ČR - Grantová agentura ČR GAP301/10/1937 GA ČR - Grantová agentura ČR IAA500520702 GA AV ČR - Akademie věd KAN200520703 GA AV ČR - Akademie věd KJB500970904 GA AV ČR - Akademie věd KAN200100801 GA AV ČR - Akademie věd CEZ AV0Z50520701 - BTO-N (2007-2013) AV0Z50520514 - UMG-J (2005-2011) AV0Z4055905 - UOCHB-X UT WOS 000290603700010 DOI 10.1016/j.freeradbiomed.2011.02.032 Anotace Mitochondria are emerging as intriguing targets for anti-cancer agents.We tested here a novel approach,whereby the mitochondrially targeted delivery of anti-cancer drugs is enhanced by the addition of a triphenylphosphonium group (TPP+). A mitochondrially targeted analog of vitamin E succinate (MitoVES),modified by tagging the parental compound with TPP+,induced considerably more robust apoptosis in cancer cells with a 1–2 log gain in anti-cancer activity compared to the unmodified counterpart, while maintaining selectivity for malignant cells.This is because MitoVES associates with mitochondria and causes fast generation of ROS that then trigger mitochondria-dependent apoptosis, involving transcriptional modulation of the Bcl-2 family proteins.MitoVES proved superior in suppression of experimental tumors compared to the untargeted analog. We propose that mitochondrially targeted delivery of anti-cancer agents offers a new paradigm for increasing the efficacy of anti-cancer compounds Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1