Počet záznamů: 1
Fluorescent magnetic nanoparticles for biomedical applications
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SYSNO ASEP 0359777 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Fluorescent magnetic nanoparticles for biomedical applications Tvůrce(i) Chekina, Nataliya (UMCH-V) RID
Horák, Daniel (UMCH-V) RID, ORCID
Jendelová, Pavla (UEM-P) RID, ORCID
Trchová, Miroslava (UMCH-V) RID, ORCID
Beneš, Milan J. (UMCH-V) RID
Hrubý, Martin (UMCH-V) RID, ORCID
Herynek, V. (CZ)
Turnovcová, Karolína (UEM-P) ORCID
Syková, Eva (UEM-P) RIDZdroj.dok. Journal of Materials Chemistry. - : ROYAL SOC CHEMISTRY - ISSN 0959-9428
Roč. 21, č. 21 (2011), s. 7630-7639Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova magnetic ; fluorescent ; stem cells Vědní obor RIV CD - Makromolekulární chemie CEP 7E09109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA203/09/1242 GA ČR - Grantová agentura ČR KAN201110651 GA AV ČR - Akademie věd KAN200200651 GA AV ČR - Akademie věd CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000290670000017 DOI 10.1039/C1JM10621J Anotace The simultaneous combination of optical and magnetic resonance imaging (MRI) would greatly benefit in vivo disease diagnosis as well as in situ monitoring of living cells. In order to design dual detection of cells involving simultaneous imaging by fluorescent microscopy and MRI, nanoparticles with two reporters, a fluorescent dye and a superparamagnetic core, included in one particle were synthesized and characterized. The γ-Fe2O3 nanoparticles obtained by coprecipitation and oxidation were coated with silica (SiO2) or carboxymethyl chitosan (CMCS) and labeled with fluorescein isothiocyanate (FITC). The fluorescent label was covalently bound to the nanoparticles and was not quenched by the iron oxide core. The nanoparticles successfully labeled rat mesenchymal stem cells (rMSCs) in vitro. Relaxation time measurements found large amounts of iron inside the cells with FITC-labeled γ-Fe2O3–SiO2-AP nanoparticles. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
Počet záznamů: 1