Počet záznamů: 1

Evolution and metabolic significance of the urea cycle in photosynthetic diatoms

SYSNO ASEP	0359538
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Evolution and metabolic significance of the urea cycle in photosynthetic diatoms
Tvůrce(i)	Allen, A. E. (US) Dupont, Ch. L. (US) Oborník, Miroslav (BC-A)_{RID, ORCID} Horák, Aleš (BC-A)_{RID, ORCID} Nunes-Nesi, A. (DE) McCrow, J. P. (US) Zheng, H. (US) Johnson, D. A. (US) Hu, H. (FR) Fernie, A. R. (DE) Bowler, Ch. (FR)
Zdroj.dok.	Nature. - : Palgrave Macmillan - ISSN 0028-0836 Roč. 473, č. 7346 (2011), s. 203-209
Poč.str.	7 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	CARBAMOYL-PHOSPHATE SYNTHETASE ; PHAEODACTYLUM-TRICORNUTUM ; MAXIMUM-LIKELIHOOD ; PHYLOGENETIC RECONSTRUCTION ; MOLECULAR EVOLUTION ; SEQUENCE ALIGNMENT ; DIVERGENCE TIMES ; MARINE DIATOMS ; MIXED MODELS ; TREE
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA206/08/1423 GA ČR - Grantová agentura ČR
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000290487200036
DOI	10.1038/nature10074
Anotace	RNA-interference-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nitrogen-limited diatoms to nitrogen addition. Intermediates in the ornithine-urea cycle are particularly depleted and both the tricarboxylic acid cycle and the glutamine synthetase/glutamate synthase cycles are linked directly with the ornithine-urea cycle. Several other metabolites are generated from this cycle by products of genes acquired from bacteria. So far, this cycle is only known for its essential role in the removal of fixed nitrogen in metazoans. In diatoms, this cycle serves as a distribution and repackaging hub for inorganic carbon and nitrogen and contributes significantly to the metabolic response of diatoms to episodic nitrogen availability. The diatomornithine-urea cycle therefore represents a key pathway for anaplerotic carbon fixation into nitrogenous compounds that are essential for diatom growth and for the contribution of diatoms to marine productivity.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2012

Počet záznamů: 1