Počet záznamů: 1
New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations
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SYSNO ASEP 0359458 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations Tvůrce(i) Brus, Jiří (UMCH-V) RID, ORCID
Urbanová, Martina (UMCH-V) RID, ORCID
Šeděnková, Ivana (UMCH-V) RID
Brusová, H. (CZ)Zdroj.dok. International Journal of Pharmaceutics. - : Elsevier - ISSN 0378-5173
Roč. 409, 1/2 (2011), s. 62-74Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova 19F MAS NMR ; factor analysis ; polymorphism Vědní obor RIV CB - Analytická chemie, separace CEP 2B08021 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000290135800008 DOI 10.1016/j.ijpharm.2011.02.030 Anotace Despite recent advances in solid-state NMR, the structural characterization of amorphous pharmaceuticals (APIs) in solid dosage forms continues to be a monumental challenge. To circumvent complications following from low concentrations of APIs in tablet formulations, we propose a new time-saving procedure based on chemometric approach: factor analysis of 19F MAS NMR spectra. Capability of the proposed method is demonstrated on atorvastatin – a typical representative of fluorinated pharmaceutical substances exhibiting extensive polymorphism. Applying the factor analysis on the recorded 19F MAS NMR spectra, unique parameters for every sample were derived. In this way every solid form of atorvastatin was characterized and clearly distinguishable even among various amorphous and disordered forms. Reliability of the proposed method was examined by comparing with other techniques and perspectives to obtain structural view on variability of amorphous products are also discussed. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
Počet záznamů: 1