Počet záznamů: 1
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting
- 1.
SYSNO ASEP 0359227 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting Tvůrce(i) Etrych, Tomáš (UMCH-V) RID, ORCID
Strohalm, Jiří (UMCH-V)
Chytil, Petr (UMCH-V) RID, ORCID
Černoch, Peter (UMCH-V) RID, ORCID
Starovoytova, Larisa (UMCH-V) RID
Pechar, Michal (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RIDZdroj.dok. European Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
Roč. 42, č. 5 (2011), s. 527-539Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova dendrimer ; HPMA copolymers ; doxorubicin Vědní obor RIV CD - Makromolekulární chemie CEP IAA400500806 GA AV ČR - Akademie věd IAAX00500803 GA AV ČR - Akademie věd GA203/08/0543 GA ČR - Grantová agentura ČR CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000290822800012 DOI 10.1016/j.ejps.2011.03.001 Anotace New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
Počet záznamů: 1