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Single-step electrospinning to bioactive polymer nanofibers
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SYSNO ASEP 0358513 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Single-step electrospinning to bioactive polymer nanofibers Tvůrce(i) Gentsch, R. (DE)
Pippig, F. (DE)
Schmidt, S. (DE)
Černoch, Peter (UMCH-V) RID, ORCID
Polleux, J. (DE)
Börner, H. G. (DE)Zdroj.dok. Macromolecules. - : American Chemical Society - ISSN 0024-9297
Roč. 44, č. 3 (2011), s. 453-461Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova electrospinning ; polymer-peptide conjugate ; block copolymer Vědní obor RIV CD - Makromolekulární chemie CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000286691500007 DOI 10.1021/ma102847a Anotace A single-step process to get polymer nanofiber meshes of biofunctional peptide segments is described in the article. A standard electrospinning of a homogeneous mixture of a polymer-peptide conjugate (poly(lactic acid)-block-CGGRGDS) and a biocompatible commodity poly(lactic-co-glycolic acid) (PLGA) leads to nonwovens with the peptide part enriched on the fiber surface. The accessibility of the peptide is proved by contact angle measurements as well as by probing electrostatic interaction between CGGRGDS surface functionalities and a colloidal silica probe via AFM. Bioavailability and bioactivity tests on the fiber surface demonstrate that the meshes promote adhesion and migration of fibroblasts in comparison to pure PLGA meshes. The one-step production of PLGA-based fibers could be exploited to electrospin into living cell culture without indication of toxic adverse effects on cell proliferation. This might be useful for production of cell-loaded scaffolds or biohybrid materials. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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