Počet záznamů: 1

Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors

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    SYSNO ASEP0357894
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    NázevTrisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors
    Tvůrce(i)Hyun, T.K. (AT) - Havlíček, Libor (UEB-Q) - Strnad, Miroslav (UEB-Q) - Roitsch, T. (AT)
    Rozsah stran553 - 557
    Zdroj.dok.Biosciences Biotechnology and Biochemistry - ISSN 0916-8451
    Poč.str.5 s.
    Jazyk dok.eng - angličtina
    Země vyd.JP - Japonsko
    Klíč. slovamitogen-activated protein kinase (MAPK) ; trisubstituted purines ; inhibitor
    Vědní obor RIVFD - Onkologie a hematologie
    CEPGA301/08/1649 GA ČR - Grantová agentura ČR
    CEZAV0Z50380511 - UEB-Q (2005-2011)
    UTISI000276541600017
    DOI10.1271/bbb.90743
    AnotaceA number of compounds have been reported to be specific inhibitors of protein kinases mediated by structural-based selectivity,but the development of specific inhibitors has not yet been addressed in plant science.Here we tested C2,C6,and N9-trisubstituted purines to determine the basic relationship between their chemical structure and inhibitory activity versus a plant mitogen-activated protein kinase (MAPK).Modification of substitution at positions C2 and N9 caused increased inhibitory activity of 6-benzylaminopurine analogs.In the case of 6-isopentenyladenine derivatives, the addition of a methyl group at position N9 caused at least 2-fold increased inhibitory activity, as compared with the addition of an isopropyl group. The data indicate that the selectivity and potency of inhibitors can be improved by modification of the chemical structure, suggesting that trisubstituted purines are powerful tools for probing biological processes and understanding the physiological roles of MAPK signaling.
    PracovištěÚstav experimentální botaniky
    KontaktDavid Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
    Rok sběru2011