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Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors
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SYSNO ASEP 0357894 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors Tvůrce(i) Hyun, T.K. (AT)
Havlíček, Libor (UEB-Q) RID, ORCID
Strnad, Miroslav (UEB-Q) RID, ORCID
Roitsch, T. (AT)Zdroj.dok. Biosciences Biotechnology and Biochemistry - ISSN 0916-8451
Roč. 74, č. 3 (2010), s. 553-557Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. JP - Japonsko Klíč. slova mitogen-activated protein kinase (MAPK) ; trisubstituted purines ; inhibitor Vědní obor RIV FD - Onkologie a hematologie CEP GA301/08/1649 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000276541600017 DOI 10.1271/bbb.90743 Anotace A number of compounds have been reported to be specific inhibitors of protein kinases mediated by structural-based selectivity,but the development of specific inhibitors has not yet been addressed in plant science.Here we tested C2,C6,and N9-trisubstituted purines to determine the basic relationship between their chemical structure and inhibitory activity versus a plant mitogen-activated protein kinase (MAPK).Modification of substitution at positions C2 and N9 caused increased inhibitory activity of 6-benzylaminopurine analogs.In the case of 6-isopentenyladenine derivatives, the addition of a methyl group at position N9 caused at least 2-fold increased inhibitory activity, as compared with the addition of an isopropyl group. The data indicate that the selectivity and potency of inhibitors can be improved by modification of the chemical structure, suggesting that trisubstituted purines are powerful tools for probing biological processes and understanding the physiological roles of MAPK signaling. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2011
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