Počet záznamů: 1
Differential expression of non-coding RNAs and continuous evolution of the X chromosome in testicular transcriptome of two mouse species
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SYSNO ASEP 0356977 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Differential expression of non-coding RNAs and continuous evolution of the X chromosome in testicular transcriptome of two mouse species Tvůrce(i) Homolka, David (UMG-J)
Ivánek, Robert (UMG-J)
Forejt, Jiří (UMG-J) RID, ORCID
Jansa, Petr (UMG-J) RIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 6 (2011), e17198-e17198Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova spermatogenesis ; tiling array ; expression profiles Vědní obor RIV EB - Genetika a molekulární biologie CEP GA301/07/1383 GA ČR - Grantová agentura ČR 1M0520 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000287367600041 DOI 10.1371/journal.pone.0017198 Anotace Tight regulation of testicular gene expression is a prerequisite for male reproductive success, while differentiation of gene activity in spermatogenesis is important during speciation. We compared testicular transcriptomes of two closely related mouse species, Mus musculus and Mus spretus. We analyzed testicular expression using tiling arrays overlapping Chromosomes 2, X, Y and mitochondrial genome. An excess of differentially regulated non-coding RNAs was found on Chromosome 2 including the intronic antisense RNAs, intergenic RNAs and premature piRNAs. This indicates the role of non-coding RNAs in species-specific regulation of spermatogenesis. A striking difference was found in the expression of X-linked G6pdx gene, the parental gene of the autosomal retrogene G6pd2. The postmeiotic expression of G6pdx in Mus spretus points towards the continuous evolution of X-chromosome silencing and provides an example of expression change accompanying the out-of-the X-chromosomal retroposition. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
Počet záznamů: 1