Počet záznamů: 1
Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material
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SYSNO ASEP 0356676 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material Tvůrce(i) Sperlingova, I. (CZ)
Dabrowská, L. (CZ)
Stránský, V. (CZ)
Duskova, S. (CZ)
Kučera, Jan (UJF-V) RID, ORCID, SAI
Tvrdíková, M. (CZ)
Tichý, M. (CZ)Zdroj.dok. Analytical and Bioanalytical Chemistry. - : Springer - ISSN 1618-2642
Roč. 397, č. 2 (2010), s. 433-438Poč.str. 6 s. Akce 12th International Symposium on Biological and Environmental Reference Materials Keble Coll Datum konání 07.07.2009-10.07.2009 Místo konání Oxford Země GB - Velká Británie Typ akce EUR Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Candidate reference material ; Ethylene glycol monobutyl ether ; Metabolite Vědní obor RIV BG - Jaderná, atomová a mol. fyzika, urychlovače CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000276768400004 DOI 10.1007/s00216-009-3148-3 Anotace Ethylene glycol monobutyl ether (EGBE), an industrial solvent, is absorbed by the body not only by inhalation but also by dermal absorption (liquid or vapour). EGBE is metabolized to butoxyacetic acid (BAA). Pooled freeze-dried urine candidate reference material (RM) was prepared from urine obtained from persons occupationally exposed to EGBE. This material has the advantage of containing butoxyacetic acid in both the free and conjugated (glutamine and glycine) forms, as found in native urine. In all GC method modifications used, acid hydrolysis was used to release BAA from its conjugated form. The amount of butoxyacetic acid in homogeneity and stability testing was measured by GC after derivatisation with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide. Detection was by MS in EI mode, in the authors' laboratory. For interlaboratory comparison of the reference material GC methods with MS, FID, and ECD were used. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2011
Počet záznamů: 1