Počet záznamů: 1

Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material

SYSNO ASEP	0356676
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material
Tvůrce(i)	Sperlingova, I. (CZ) Dabrowská, L. (CZ) Stránský, V. (CZ) Duskova, S. (CZ) Kučera, Jan (UJF-V)_{RID, ORCID, SAI} Tvrdíková, M. (CZ) Tichý, M. (CZ)
Zdroj.dok.	Analytical and Bioanalytical Chemistry. - : Springer - ISSN 1618-2642 Roč. 397, č. 2 (2010), s. 433-438
Poč.str.	6 s.
Akce	12th International Symposium on Biological and Environmental Reference Materials Keble Coll
Datum konání	07.07.2009-10.07.2009
Místo konání	Oxford
Země	GB - Velká Británie
Typ akce	EUR
Jazyk dok.	eng - angličtina
Země vyd.	DE - Německo
Klíč. slova	Candidate reference material ; Ethylene glycol monobutyl ether ; Metabolite
Vědní obor RIV	BG - Jaderná, atomová a mol. fyzika, urychlovače
CEZ	AV0Z10480505 - UJF-V (2005-2011)
UT WOS	000276768400004
DOI	10.1007/s00216-009-3148-3
Anotace	Ethylene glycol monobutyl ether (EGBE), an industrial solvent, is absorbed by the body not only by inhalation but also by dermal absorption (liquid or vapour). EGBE is metabolized to butoxyacetic acid (BAA). Pooled freeze-dried urine candidate reference material (RM) was prepared from urine obtained from persons occupationally exposed to EGBE. This material has the advantage of containing butoxyacetic acid in both the free and conjugated (glutamine and glycine) forms, as found in native urine. In all GC method modifications used, acid hydrolysis was used to release BAA from its conjugated form. The amount of butoxyacetic acid in homogeneity and stability testing was measured by GC after derivatisation with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide. Detection was by MS in EI mode, in the authors' laboratory. For interlaboratory comparison of the reference material GC methods with MS, FID, and ECD were used.
Pracoviště	Ústav jaderné fyziky
Kontakt	Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228
Rok sběru	2011

Počet záznamů: 1