Počet záznamů: 1
Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic
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SYSNO ASEP 0356231 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic Tvůrce(i) Rössner ml., Pavel (UEM-P) RID, ORCID
Tabashidze, Nana (UEM-P)
Dostál, Miroslav (UEM-P) RID
Nováková, Zuzana (UEM-P)
Chvátalová, Irena (UEM-P)
Špátová, Milada (UEM-P)
Šrám, Radim (UEM-P) RIDZdroj.dok. Environmental Health Perspectives. - : U.S. Department of Health and Human Services - ISSN 0091-6765
Roč. 119, č. 2 (2011), s. 265-271Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova air pollution ; biomarkers ; genetic polymorphisms Vědní obor RIV DN - Vliv životního prostředí na zdraví CEP SP/1B3/50/07 GA MŽP - Ministerstvo životního prostředí CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000286803400031 EID SCOPUS 79955788755 DOI 10.1289/ehp.1002470 Anotace We investigated associations between the levels of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn’s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1