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Loss of the response regulator CtrA causes pleiotropic effects on gene expression but does not affect growth phase regulation in Rhodobacter capsulatus
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SYSNO ASEP 0356033 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Loss of the response regulator CtrA causes pleiotropic effects on gene expression but does not affect growth phase regulation in Rhodobacter capsulatus Tvůrce(i) Mercer, R.G. (CA)
Callister, S.J. (US)
Lipton, M.S. (US)
Pasa-Tolic, L. (US)
Strnad, Hynek (UMG-J) RID
Pačes, Václav (UMG-J) RID
Beatty, J.T. (CA)
Lang, A.S. (CA)Zdroj.dok. Journal of Bacteriology. - : American Society for Microbiology - ISSN 0021-9193
Roč. 192, č. 11 (2010), s. 2701-2710Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Gene transfer agent ; ctrA regulator protein ; gene expression Vědní obor RIV EB - Genetika a molekulární biologie CEP 1M0520 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000277549300005 DOI 10.1128/JB.00160-10 Anotace The CtrA protein in Caulobacter crescentus has been thoroughly studied for its role as an essential, master regulator of the cell cycle. Although the CtrA protein in R. capsulatus shares a high degree of sequence similarity with the C. crescentus protein, it is nonessential and clearly plays a different role in this bacterium. We have used transcriptomic and proteomic analyses of wild-type and ctrA mutant cultures to identify the genes dysregulated by the loss of CtrA in R. capsulatus. We have also characterized gene expression differences between the logarithmic and stationary phases of growth. Loss of CtrA has pleiotropic effects, with dysregulation of expression of approximately 6% of genes in the R. capsulatus genome. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
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