Počet záznamů: 1

Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation

SYSNO ASEP	0355817
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation
Tvůrce(i)	Philimonenko, Anatoly (UMG-J) Janáček, Jiří (FGU-C)_{RID, ORCID} Snyers, L. (AT) Almeder, M. (AT) Berger, W. (AT) Schmidt, W. (AT) Schofer, C. (AT) Hozák, Pavel (UMG-J)_{RID, ORCID}
Zdroj.dok.	Journal of Structural Biology. - : Elsevier - ISSN 1047-8477 Roč. 173, č. 2 (2011), s. 382-390
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Chromosome territory ; Gene expression ; Confocal imaging
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	LC545 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LC06063 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	2B06063 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z50520514 - UMG-J (2005-2011)
	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000286846700021
DOI	10.1016/j.jsb.2010.10.010
Anotace	In this study we analyzed the position of the cell cycle regulator gene p21 within the CT of human chromosome 6 (HSA6) upon transcriptional activation. Whereas the majority of active p21 genes is located in the interior of the CT of HSA6, induction of p21 transcription correlates with increased variation of gene localization within the CT and with a higher percentage of p21 genes located at the periphery of the CT. Additionally it demonstrates once more that transcription can take place throughout CTs. Comparison of the p21 locus with two non-coding regions on HSA6 showed that both non-coding sequences are located more frequently in the interior of the CT than p21 genes although they are situated in chromosomal neighborhoods with widely differing gene density and regional transcriptional activity. Thus our data support models describing an influence of the transcriptional activity of a gene on the localization within its CT.
Pracoviště	Ústav molekulární genetiky
Kontakt	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Rok sběru	2011

Počet záznamů: 1