Počet záznamů: 1

Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila

SYSNO ASEP	0355637
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Equilibrative nucleoside transporter 2 regulates olfactory memory and synaptic function in Drosophila
Tvůrce(i)	Knight, D. (CA) Harvey, P. J. (CA) Iliadi, K. G. (CA) Klose, M. K. (CA) Iliadi, N. (CA) Doleželová, Eva (BC-A)_RID Charlton, M. P. (CA) Žurovec, Michal (BC-A)_{RID, ORCID} Boulianne, G. L. (CA)
Celkový počet autorů	9
Zdroj.dok.	Journal of Neuroscience. - : Society for Neuroscience - ISSN 0270-6474 Roč. 30, č. 14 (2010), s. 5047-5057
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Drosophila
Vědní obor RIV	ED - Fyziologie
CEP	LC06077 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z50070508 - ENTU-I, BC-A (2005-2011)
UT WOS	000276414800025
DOI	10.1523/JNEUROSCI.6241-09.2010
Anotace	Nucleoside transporters are evolutionarily conserved proteins that are essential for normal cellular function. In the present study, we examined the role of equilibrative nucleoside transporter 2 (ent2) in Drosophila. Null mutants of ent2 are lethal during late larval/early pupal stages, indicating that ent2 is essential for normal development. Hypomorphic mutant alleles of ent2, however, are viable and exhibit reduced associative learning. We additionally used RNA interference to knock down ent2 expression in specific regions of the CNS and show that ent2 is required in the alpha/beta lobes of the mushroom bodies and the antennal lobes. To determine whether the observed behavioral defects are attributable to defects in synaptic transmission, we examined transmitter release at the larval neuromuscular junction (NMJ). Excitatory junction potentials were significantly elevated in ent2 mutants, whereas paired-pulse plasticity was reduced.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2011

Počet záznamů: 1