Počet záznamů: 1

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

SYSNO ASEP	0355121
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
Tvůrce(i)	Brabek, J. (CZ) Mierke, C.T. (DE) Rosel, D. (CZ) Veselý, Pavel (UMG-J) Fabry, B. (DE)
Zdroj.dok.	Cell communication and signaling : CCS Roč. 8, č. 22 (2010), 22e-22e
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	endothelial barrier function ; pericellular proteolysis ; melanoma cells
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	LC06061 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000282265700003
DOI	10.1186/1478-811X-8-22.
Anotace	During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion.
Pracoviště	Ústav molekulární genetiky
Kontakt	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Rok sběru	2011

Počet záznamů: 1