Počet záznamů: 1

Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling

SYSNO ASEP	0355105
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling
Tvůrce(i)	Ježek, Jan (FGU-C)_{RID, ORCID} Jabůrek, Martin (FGU-C)_{ORCID, RID} Zelenka, Jaroslav (FGU-C)_RID Ježek, Petr (FGU-C)_{RID, ORCID}
Zdroj.dok.	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 59, č. 5 (2010), s. 737-747
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	CZ - Česká republika
Klíč. slova	Heart mitochondrial phospholipase A2 ; Fatty Acids ; Adenine nucleotide translocase
Vědní obor RIV	ED - Fyziologie
CEP	GA303/07/0105 GA ČR - Grantová agentura ČR
	ME09018 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	KJB500110902 GA AV ČR - Akademie věd
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000284489300013
Anotace	Homeostasis of reactive oxygen species in cardiomyocytes is critical for elucidation of normal heart physiology and pathology. Mitochondrial phospholipases A2 have been previously suggested to be activated by ROS. We have found that function of a specific i-isoform of mitochondrial phospholipase A2is activated by tert-butylhydroperoxide in isolated rat heart mitochondria. Concomitant uncoupling has been caused by free fatty acids, since it was inhibited by bovine serum albumin. Since this uncoupling was sensitive to carboxyatractyloside and purine nucleotide di- and tri- phosphates, we conclude that it originated from the onset of fatty acid cycling mediated by the adenine nucleotide translocase (major contribution) and mitochondrial uncoupling protein(s) (minor contribution), respectively. In conclusion, ROS-induced function of cardiac mt-iPLA2 may stand on a pro-survival side of ischemia-reperfusion injury
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2011

Počet záznamů: 1