Počet záznamů: 1
The suboptimal structures find the optimal RNAs: homology search for bacterial non-coding RNAsusing suboptimal RNA structures
- 1.
SYSNO ASEP 0354394 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The suboptimal structures find the optimal RNAs: homology search for bacterial non-coding RNAsusing suboptimal RNA structures Tvůrce(i) Pánek, Josef (MBU-M) RID
Krásný, Libor (MBU-M) RID, ORCID
Bobek, Jan (MBU-M)
Ježková, E. (CZ)
Korelusová, Jana (MBU-M)
Vohradský, Jiří (MBU-M) RID, ORCIDZdroj.dok. Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
-, - (2010), s. 1-9Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova ncRNAs ; RNA structures Vědní obor RIV EE - Mikrobiologie, virologie CEP 2B06065 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA303/09/0475 GA ČR - Grantová agentura ČR GA310/07/1009 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000290055200040 DOI 10.1093/nar/gkq1186 Anotace Non-coding RNAs (ncRNAs) are regulatory molecules encoded in the intergenic or intragenic regions of the genome. In prokaryotes, biocomputational identification of homologs of known ncRNAs in other species often fails due to weakly evolutionarily conserved sequences, structures, synteny and genome localization, except in the case of evolutionarily closely related species. To eliminate results from weak conservation, we focused on RNA structure, which is the most conserved ncRNA property. Analysis of the structure of one of the few wellstudied bacterial ncRNAs, 6S RNA, demonstrated that unlike optimal and consensus structures, suboptimal structures are capable of capturing RNA homology even in divergent bacterial species. A computational procedure for the identification of homologous ncRNAs using suboptimal structures was created. The suggested procedure was applied to strongly divergent bacterial species and was capable of identifying homologous ncRNAs Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2011
Počet záznamů: 1