Počet záznamů: 1
Carbohydrate Chemistry. Chemical and Biological Approaches
- 1.
SYSNO ASEP 0354023 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Azido leaving group in enzymatic synthesis-small and efficient Tvůrce(i) Bojarová, Pavla (MBU-M) ORCID
Křen, Vladimír (MBU-M) RID, ORCIDZdroj.dok. Carbohydrate Chemistry. Chemical and Biological Approaches. - Thomas Graham House, Science Park, Milton Road : The Royal Society of Chemistry, 2010 / Rauter A. P. ; Lindhorst K. T. - ISBN 9781847550446 Rozsah stran s. 168-175 Poč.str. 6 s. Poč.výt. 1300 Poč.str.knihy 193 Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova carbohydrate synthesis ; glycoside donors ; glycosyl azides Vědní obor RIV CC - Organická chemie CEP OC08049 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy DOI - Anotace Enzymatic transglycosylation catalyzed by glycosidases is a respected method in carbohydrate synthesis. The spectrum of acceptors is practically infinite, contrary to glycosyl donors, which are usually nitrophenyl glycosides. Their major advantage is good reactivity, however, their low water solubility causes lower transglycosylation yields since high concentrations of substrates are needed to promote transglycosylation at the expense of donor hydrolysis. This is especially the case of modified glycoside donors where some OH groups are substituted with more lipophilic substituents. The solubility problems are generally incurred by hydrophobic leaving groups. Furthermore, commercial nitrophenyl glycosides are expensive and the yields of their syntheses may be unsatisfactory. Therefore, alternative glycosyl donors are emerging, such as 3-nitro- and 5-nitro-2-pyridyl glycosides, vinyl glycosides and glycosyl fluorides, which exhibit many properties common to glycosyl azides Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2011
Počet záznamů: 1