Počet záznamů: 1
Distribution and development of the postnatal murine V delta 1 T-cell receptor repertoire
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SYSNO ASEP 0352860 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Distribution and development of the postnatal murine V delta 1 T-cell receptor repertoire Tvůrce(i) Holtmeier, W. (DE)
Gille, J. (DE)
Zeuzem, S. (DE)
Šinkora, Marek (MBU-M) RID, ORCIDZdroj.dok. Immunology - ISSN 0019-2805
Roč. 131, č. 2 (2010), s. 192-201Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova gene rearrangement ; repertoire development ; rodent Vědní obor RIV EE - Mikrobiologie, virologie CEP GA524/07/0087 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000281554600005 DOI 10.1111/j.1365-2567.2010.03290.x Anotace Murine gamma/delta T cells express canonical V gamma 5V delta 1 chains in the epidermis and V gamma 6V delta 1 chains at reproductive sites. Both subsets carry an identical V delta 1-D delta 2-J delta 2 chain which completely lacks junctional diversity. These cells are thought to monitor tissue integrity via recognition of stress-induced self antigens. In this study, we showed by reverse transcription-polymerase chain reaction (RT-PCR), complementarity determining region 3 (CDR3) spectratyping and sequencing of the junctional regions of V delta 1 chains from C57BL/6 mice (aged 1 day to 14 months) that the canonical V delta 1-D delta 2-J delta 2 chain is also consistently present at other sites such as the thymus, gut, lung, liver, spleen and peripheral blood Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2011
Počet záznamů: 1