Počet záznamů: 1

1,3-Butadiene: Biomarkers and application to risk assessment

SYSNO ASEP	0350229
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	1,3-Butadiene: Biomarkers and application to risk assessment
Tvůrce(i)	Swenberg, J. A. (US) Bordeerat, N. K. (US) Boysen, G. (US) Carro, S. (US) Georgieva, N. I. (US) Troutman, J. M. (US) Upton, P. B. (US) Albertini, R. J. (US) Vacek, P. M. (US) Walker, V. E. (US) Šrám, Radim (UEM-P)_RID Goggin, M. (US) Tretyakova, N. (US)
Zdroj.dok.	Chemico-Biological Interactions. - : Elsevier - ISSN 0009-2797 Roč. 192, 1-2 (2011), s. 150-154
Poč.str.	5 s.
Jazyk dok.	eng - angličtina
Země vyd.	IE - Irsko
Klíč. slova	risk assessment ; 1,3-butadiene ; occupational exposure
Vědní obor RIV	DN - Vliv životního prostředí na zdraví
CEZ	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000292435100026
EID SCOPUS	79958022697
DOI	10.1016/j.cbi.2010.10.010
Anotace	1,3-Butadiene (BD) is a known human carcinogen that is metabolized mainly by P450 2E1 to three epoxides (EB, DEB and EB-diol). These epoxides vary in their mutagenic potency, with DEB being the most mutagenic metabolite. It is important to understand the internal formation of the individual epoxides to assign the relative risk for each metabolite and to understand the molecular mechanisms responsible for differences in carcinogenicity. In the extensive exposure-biomarker studies on mice, rats and humans was found that using low exposures that range from current occupational levels to human exposures from tobacco smoke mice are very different from humans, with mice forming 200 times more DEB than humans at exposures of 0.1-1.5ppm BD. These data provide a scientific basis for improved risk assessment of BD.
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2012

Počet záznamů: 1