Počet záznamů: 1

Anticancer activity of natural cytokinins: A structure-activity relationship study

SYSNO ASEP	0349823
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Anticancer activity of natural cytokinins: A structure-activity relationship study
Tvůrce(i)	Voller, Jiří (UEB-Q)_{RID, ORCID} Zatloukal, Marek (UEB-Q)_ORCID Lenobel, René (UEB-Q)_ORCID Doležal, Karel (UEB-Q)_{RID, ORCID} Béres, Tibor (UEB-Q)_RID Kryštof, Vladimír (UEB-Q)_{RID, ORCID} Spíchal, Lukáš (UEB-Q)_{RID, ORCID} Niemann, P. (DE) Džubák, P. (CZ) Hajdúch, M. (CZ) Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Zdroj.dok.	Phytochemistry. - : Elsevier - ISSN 0031-9422 Roč. 41, 11-12 (2010), s. 1350-1359
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	SAR ; Cytokinins ; Cancer
Vědní obor RIV	FD - Onkologie a hematologie
CEP	GA301/08/1649 GA ČR - Grantová agentura ČR
	GA206/09/1284 GA ČR - Grantová agentura ČR
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000280321000017
DOI	10.1016/j.phytochem.2010.04.018
Anotace	This study presents the first analysis of relationship between chemical structure of cytokinins and their cytotoxic effects against a panel of human cancer cell lines with diverse histopatothological origin. The results confirm the cytotoxic activity of N6-isopentenyladenosine, kinetin riboside, and N6-benzyladenosine and show that the spectrum of cell lines that are sensitive to these compounds is wider than previously reported. The first evidence that the hydroxylated aromatic cytokinins and cis-zeatin riboside have cytotoxic activities is presented. Most cell lines showed greatest sensitivity to ortho-topolin riboside. Cytokinin nucleotides were usually active in a similar concentration range to the corresponding ribosides. However, cytokinin free bases, 2-methylthio derivatives and glucosides showed little or no toxicity. The study shows that structural requirements for cytotoxic activity of cytokinins against human cancer cell lines differ from their activity in plant bioassays.
Pracoviště	Ústav experimentální botaniky
Kontakt	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Rok sběru	2011

Počet záznamů: 1