Počet záznamů: 1

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

SYSNO ASEP	0349610
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
Tvůrce(i)	Campa, D. (DE) Pardini, Barbara (UEM-P) Naccarati, Alessio (UEM-P) Vodičková, Ludmila (UEM-P)_RID Novotný, J. (CZ) Steinke, V. (DE) Rahner, N. (DE) Holinski-Feder, E. (DE) Morak, M. (DE) Schackert, H. K. (DE) Görgens, H. (DE) Kötting, J. (DE) Betz, B. (DE) Kloor, M. (DE) Engel, C. (DE) Büttner, R. (DE) Propping, P. (DE) Försti, A. (SE) Hemminki, K. (SE) Barale, R. (IT) Vodička, Pavel (UEM-P)_RID Canzian, F. (DE)
Zdroj.dok.	BMC Gastroenterology Roč. 10, - (2010), s. 112-117
Poč.str.	6 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	colorectal cancer ; insulin ; GHSR
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA310/05/2626 GA ČR - Grantová agentura ČR
CEZ	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000282779500001
EID SCOPUS	77957116442
DOI	10.1186/1471-230X-10-112
Anotace	Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Pairwise tagging was used to select the 11 polymorphisms and the selected polymorphisms were genotyped in cases and controls from the Czech Republic and further verified on the German population. T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2011

Počet záznamů: 1