Počet záznamů: 1
Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease
- 1.
SYSNO ASEP 0349469 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease Tvůrce(i) Olabarria, M. (GB)
Noristani, H. N. (GB)
Verkhratsky, Alexei (UEM-P)
Rodríguez Arellano, Jose Julio (UEM-P)Zdroj.dok. Glia. - : Wiley - ISSN 0894-1491
Roč. 58, č. 7 (2010), s. 831-838Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova astroglia ; Alzheimer's disease ; hippocampus Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000276678500008 EID SCOPUS 77952573750 DOI 10.1002/glia.20967 Anotace We monitored changes in the astroglia morphology throughout the age-dependent progression of AD, in the hippocampus of a triple transgenic mouse model of AD (3xTg-AD) that mimics the temporal progression of the human disease. We found astrocytic atrophy in both the dentate gyrus and hippocampal CA1 field from middle age (12 months onwards). However, astroglial atrophy appears as a generalised process, astrocytes that surround neuritic plaques are clearly hypertrophic which suggest differential effects of AD on astroglial populations depending on their association with plaques which account for the progressive disruption of connectivity in neural networks and neurotransmitters imbalance which underlie cognitive impairments observed in AD. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1