Počet záznamů: 1
Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae)
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SYSNO ASEP 0349266 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae) Tvůrce(i) Cahlíková, L. (CZ)
Macáková, K. (CZ)
Kuneš, J. (CZ)
Kurfürst, Milan (UCHP-M)
Opletal, L. (CZ)
Cvačka, Josef (UOCHB-X) RID, ORCID
Chlebek, J. (CZ)
Blunden, G. (GB)Zdroj.dok. Natural Product Communications - ISSN 1934-578X
Roč. 5, č. 7 (2010), s. 1035-1038Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova eschscholzia californica ; papaveraceae ; isoquinoline Vědní obor RIV CI - Průmyslová chemie a chemické inženýrství CEZ AV0Z40720504 - UCHP-M (2005-2011) AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000280117300010 Anotace The roots and aerial parts of Eschscholzia californica Cham. (Papaveraceae) were extracted with ethanol. Repeated column chromatography, preparative TLC, and crystallization led to the isolation of fourteen isoquinoline alkaloids, the structures of which were determined on the basis of spectroscopic techniques and by comparison with literature values. One of the compounds isolated, 1-(3-hydroxy-4-methoxybenzyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (14), has not previously been isolated from a natural source. All isolated compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibition activity. None of the compounds isolated significantly inhibited both HuAChE and HuBuChE, but the two benzylisoquinoline alkaloids, reticuline 9 and 14, showed promising inhibitory activity against HuBuChE. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2011
Počet záznamů: 1